Epinephrine infusions in panic disorder: a double-blind placebo-controlled study

Twenty-four subjects with Panic Disorder were infused with
epinephrine in physiological doses or placebo according to a
double-blind design. The panic rate in the epinephrine group
(67%) was higher than in the placebo group (25%). Placebo
panic occurred early during the procedure and was apparently
associated with anticipation anxiety and stress-provoking
situational factors. Panickers were characterized by a
greater increase inheart rate as well as a drop in pCO2.
Fear of bodily sensationswas only weakly associated with
state anxiety levels at point of panic. It is concluded that
cognitive factors may not be important in epinephrine-induced

Veltman DJ, van Zijderveld GA, van Dyck R

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