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Epitope mapping of the immunodominant invariable region of Borrelia burgdorferi VlsE in three host species.

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Abstract

VlsE, the variable surface antigen of Borrelia burgdorferi, contains a 26-amino-acid-long immunodominant invariable region, IR(6). In the present study, three overlapping 14-mer peptides reproducing the sequence of IR(6) were used as peptide-based enzyme-linked immunosorbent assay antigens to map this invariable region in infected monkeys, mice, and human
Lyme disease patients. Antibodies of the two primate species appeared to recognize IR(6) as a single antigenic determinant, while mouse antibodies recognized multiple epitopes within this region.

Infect Immun. 2000 Apr;68(4):2349-52. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.

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