Epstein-Barr virus infection associated with interstitial nephritis & chronic fatigue

Severe renal disease in the setting of Epstein-Barr virus

(EBV) infection is exceedingly rare. We report here the case

of a 22-year-old man with acute EBV infection associated with

severe interstitial nephritis. The patient developed chronic

fatigue and chronic renal failure with a serological profile

typical of primary EBV infection. Clinical improvement with

anti-EBNA seroconversion occurred after acyclovir therapy.

Our patient illustrates that chronic fatigue with major organ

dysfunction and a serological profile of primary infection

can be seen in chronic EBV infection. In such a case,

acyclovir may prove beneficial.

Lopez-Navidad A, Domingo P, Lopez-Talavera JC, Rabella N, Verger G