Severe renal disease in the setting of Epstein-Barr virus
(EBV) infection is exceedingly rare. We report here the case
of a 22-year-old man with acute EBV infection associated with
severe interstitial nephritis. The patient developed chronic
fatigue and chronic renal failure with a serological profile
typical of primary EBV infection. Clinical improvement with
anti-EBNA seroconversion occurred after acyclovir therapy.
Our patient illustrates that chronic fatigue with major organ
dysfunction and a serological profile of primary infection
can be seen in chronic EBV infection. In such a case,
acyclovir may prove beneficial.
Lopez-Navidad A, Domingo P, Lopez-Talavera JC, Rabella N, Verger G