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Evaluation of the usefulness cerebrospinal fluid myelin basic protein (MBP) concentration examination in patients with Lyme neuroborreliosis–preliminary study.

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Abstract

The aim of the study was evaluation of usefulness of cerebrospinal fluid (CSF) myelin basic protein (MBP) level examination in diagnostics of
Lyme neuroborreliosis. The study was performed in 24 subjects. In all individuals CSF MBP concentration was estimated on the 1st day of hospitalization. In patients with depressive and cognitive impairments, proved in neuropsychological tests (group I), mean CSF MBP concentration was 3.1 ng/mL, whereas in subjects without abnormalities in tests (group II), respectively, 1.2 ng/mL. The difference of mean CSF MBP levels was statistically significant (p<0.01). The obtained results indicate usefulness of this CSF parameter, besides neuropsychological tests, in objective evaluation of clinical state in patients with chronic
Lyme neuroborreliosis.

Przegl Epidemiol. 2009;63(4):539-43. Comparative Study; English Abstract; Evaluation Studies

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