Expertise in setting appropriate, answerable clinical questions, undertaking an accurate search of databases, and appraising the evidence found are all key elements to practising evidence-based medicine. Using the published evidence of the utility of donepezil in Alzheimer’s disease as an example, I have attempted to illustrate the process of critical appraisal of a therapeutic intervention. The study appraised was well conducted and the results indicate that donepezil may benefit some patients with Alzheimer’s disease.
Source: J Psychopharmacol 1999;13(3):308-12
PMID: 10512093, UI: 99440644
(Imperial College of Science, Technology and Medicine, St Charles Hospital, London, UK. email@example.com )