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Evidence for abnormal cytokine expression in Gulf War Illness: A preliminary analysis of daily immune monitoring data

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Note: You can read the full article HERE.

By L. Parkitny et al.
 
Abstract

Background: Gulf War Illness (GWI) is a clinically heterogeneous chronic condition that affects many veterans of the 1990–1991 Persian Gulf War. One of the most prevalent and debilitating symptoms of GWI is abnormal fatigue. The mechanisms underlying GWI generally, and fatigue symptoms specifically, have yet to be conclusively identified, although immune system abnormalities are suspected to be involved. The first goal of this immune monitoring study was to determine if GWI is associated with higher absolute levels and daily variability of pro-inflammatory immune factors. The second goal was to explore the relationship between day-to-day immune marker fluctuations and daily self-reported fatigue severity.
 
Methods: We recruited veterans with GWI and healthy veteran control (HV) participants to provide self-reported fatigue severity data and blood samples, over 25 consecutive days. We profiled inflammatory processes by using a longitudinal, daily immune-monitoring approach. For each day, serum cytokine and chemokine concentrations were determined using multiplex assays.
 
Results: Seven veterans with GWI and eight healthy veteran control (HV) participants completed the study protocol. We found that GWI was associated with higher variability in the expression of eotaxin-1 (p < 0.001). For GWI participants, higher fatigue severity days were associated with greater IL-1β (p = 0.008) and IL-15 (p < 0.001).

Conclusions: Our findings provide preliminary evidence that the immune system is involved in the pathophysiology of GWI. Longitudinal immune profiling approaches may be helpful in discovering targets for novel therapies in conditions such as GWI.

© 2015 Parkitny et al.
 
Source: Luke Parkitny, Stephanie Middleton, Katharine Baker and Jarred Younger. Evidence for abnormal cytokine expression in Gulf War Illness: A preliminary analysis of daily immune monitoring data. BMC Immunology 2015, 16:57  doi:10.1186/s12865-015-0122-z

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2 thoughts on “Evidence for abnormal cytokine expression in Gulf War Illness: A preliminary analysis of daily immune monitoring data”

  1. JPR1967 says:

    7 and 8 really? I wish we can get to the big studies man. It’s been a long time waiting. Thats all I am saying.

    1. LukeParkitny says:

      Hello:

      Thank you for your interest and taking the time to comment. You are absolutely correct that we need to conduct more larger studies in GWI.
      We are in fact currently doing this – including continuing to recruit for this study. In this case, after we moved from Stanford to UAB we took the opportunity to examine the data we already had and decided to publish because of the potentially important findings. The study is ongoing and we’re working hard to get answers.

      Thanks again!

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