Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia (FM) & Chronic Fatigue Syndrome (CFS)

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Fibromyalgia (FM) and chronic fatigue syndrome (CFS) fall into the

spectrum of what might be termed stress-associated syndromes

by virtue of frequent onset after acute or chronic stressors

and apparent exacerbation of symptoms during periods of

physical or emotional stress. These illnesses also share

perturbation of the hypothalamic-pituitary-adrenal axis and

sympathetic stress response systems. In this article, the

authors discuss the specific neurohormonal abnormalities found

in FM and CFS and potential mechanisms by which dysfunction

of neurohormonal stress-response systems could contribute to

vulnerability to stress-associated syndromes and to the

symptoms of FM and CFS.