By James N. Baraniuk and Narayan Shivapurkar
Levels were equivalent between nonexercise GWI (n=22), CFS (n=43) and control (n=22) groups. After exercise, START (n=22) had significantly lower miR-22-3p than control (n=15) and STOPP (n=42), but higher miR-9-3p than STOPP. All post-exercise groups had significantly reduced miR-328 and miR-608 compared to nonexercise groups; these may be markers of exercise effects on the brain. Six miRNAs were significantly elevated and 12 diminished in post-exercise START, STOPP and control compared to nonexercise groups. CFS had 12 diminished miRNAs after exercise. Despite symptom overlap of CFS, GWI and other illnesses in their differential diagnosis, exercise-induced miRNA patterns in cerebrospinal fluid indicated distinct mechanisms for post-exertional malaise in CFS and START and STOPP phenotypes of GWI.
Source: James N. Baraniuk and Narayan Shivapurkar. Exercise – induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects. Naure.com. Scientific Reports 7, Article number: 15338 (2017) doi:10.1038/s41598-017-15383-9 (Full article)