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Fatigue in chronic inflammation – a link to pain pathways

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Editor’s note: This study concludes that fatigue and pain are two symptoms that are frequently present in acute or chronic high-grade inflammatory diseases such as infection, (including Lyme disease). These symptoms are also often associated with depression.  Indeed, many doctors contend that most Lyme symptoms are caused by inflammation, or the body’s immune response to the organisms, and not the pathogenic organisms themselves. Therefore, mitigating inflammation in Lyme with various nutritional supplements such as turmeric, along with other strategies, can help to reduce symptoms of fatigue, pain and depression, among other symptoms caused by inflammation.  
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Fatigue is a frequent symptom in several inflammatory diseases, particularly in rheumatic diseases. Elements of disease activity and cognitive and behavior aspects have been reported as causes of fatigue in patients with rheumatoid arthritis. Fatigue could be associated with activity of inflammatory rheumatism. Indeed, biologic agents targeting inflammatory cytokines are effective in fatigue.
Fatigue is also associated with pain and depressive symptoms. Different pathways could be involved in fatigue and interact: the immune system with increased levels of pro-inflammatory cytokines (interleukin-1 and -6 and tumor necrosis factor alpha), dysregulation of the hypothalamic-pituitary-adrenal axis and neurological phenomena involving the central and autonomic nervous systems.
A pro-inflammatory process could be involved in pain and behavioral symptoms. Inflammation could be a common link between fatigue, pain, and depression.
Source: By K. Louati, F. Berenbaum. Fatigue in chronic inflammation – a link to pain pathways. Arthritis Res Ther. 2015 Oct 5;17:254. doi: 10.1186/s13075-015-0784-1.

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