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Fibromyalgia (FM): chronobiological aspects

The primary fibromyalgia syndrome (Weichteilrheumatismus)

shows a circadian rhythm of the symptoms [MCM: most prominent

in the early morning and in the early evening] and, moreover,

a seasonality of pain severeness. Although the

pathophysiologic mechanisms are unknown, the circadian

variations are well documented in the literature; the

seasonality of pain is sometimes clinically reported. In a

study on “healthy” workers, the seasonality of this disease is


Pollmann L