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Fibromyalgia (FM) & headache. Failure of serotonergic analgesia & N-methyl-D-aspartate-mediated neuronal plasticity: their common clues

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A defect in serotonergic analgesia and a hyperalgesic state

are proposed as features common to headache and fibromyalgia.

The benefit to both migraine and fibromyalgia from inhibiting

ionotropic N-methyl-D- aspartate receptor activity implies

that redundant hyperalgesia-related neuroplastic changes are

crucial for severe or chronic migraine and primary

fibromyalgia. The fact that migraine and primary fibromyalgia

share some pivotal set-up of serotonergic and excitatory amino

acid systems led us to analyse epidemiological data supporting

the hypothesis that analgesic disruption and a consequent

hyperalgesic state are mechanisms of both migraine and

fibromyalgia. Beyond demonstrating the comorbidity between

migraine and primary fibromyalgia, the data suggest that

migraine may represent a risk factor for fibromyalgia.

1 Star2 Stars3 Stars4 Stars5 Stars (19 votes, average: 3.00 out of 5)
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