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Fibromyalgia (FM) syndrome: overnight falls in arterial oxygen saturation

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PURPOSE: Sleep alterations and muscular changes suggesting

hypoxia have been reported in fibromyalgia syndrome (FS)

pathophysiology. We tested the hypothesis that patients with

FS show falls in the oxygen saturation of hemoglobin in

arterial blood (SaO2%) during sleep.

PATIENTS AND METHODS:

Overnight SaO2% was measured by digital pulse oximetry in 28

randomly selected women who met 1990 American College of

Rheumatology criteria for the diagnosis of FS and 15 similar

controls. Considering the results of pulse oximetry and in

order to evaluate the possible presence of a sleep apnea

syndrome (SAS) as the reason for the nocturnal desaturations,

the Epworth Sleepiness Scale (ESS) was mailed to the patients

and controls. Patients and controls who had a score higher

than 10 on the ESS underwent a polysomnographic study.

RESULTS: Patients with FS showed lower overnight minimum SaO2%

(86.8 +/- 1.3 versus 90.7 +/- 0.9 in controls, P < 0.05),

greater number of desaturations (8.3 +/- 1.8 versus 2.7 +/-

0.8 in controls, P < 0.05) and more desaturations/hour (1.3

+/- versus 0.4 +/- 0.1 in controls, P < 0.05), more night

minutes in SaO2% < 92% (56.3 +/- 12.9 versus 9.1 +/- 3.8 in

controls, P < 0.01) and more minutes in SaO2% < 90% (14.7 +/-

3.7 versus 2.4 +/- 1.0 in controls, P < 0.05). There were no

differences between patients with FS and controls in ESS

scores. Five patients (19.2%) in the FS group and 2 (15.4%) in

the control group had ESS scores higher than 10. One patient

had 1 control subject showed on apnea-plus-hypopnea index

higher than 5 (13 and 9, respectively) in polysomnographic

study.

CONCLUSIONS: Patients with FS showed small overnight

falls in SaO2% and spent more time during the night in SaO2%

below 92% and 90% than did the control group. These

alterations that, as a whole, are not due to the presence of

an associated SAS could be important in FS musculoskeletal

pathophysiology.

MCM: “Pts w FS showed small overnight falls in SaO2% and spent

more time during the night in SaO2% below 92% and 90% than did

the control group. These alterations that, as a whole, are

not due to the presence of an associated sleep apnea syndrome

could be important in FS musculoskeletal pathophysiology.”

1 Star2 Stars3 Stars4 Stars5 Stars (52 votes, average: 3.00 out of 5)
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