Fibromyalgia (FM) & the facts. Sense or nonsense

A recent flurry of important studies has provided critical new

information that is relevant to the contemporary understanding

of the fibromyalgia syndrome. The concept that these patients

represent solely a form of masked depression or a distinctive

syndrome of somatization is not supported by the current

facts. Rather it would appear that a characteristic peripheral

nociceptive component is modulated by an interplay of complex

central factors. A disruption of the neuroendocrine axis

controlling growth hormone production may be the link between

disturbed sleep and muscle pain, as growth hormone is produced

predominantly during stage four sleep. A paradigm to link some

of these newer findings is presented.

Bennett RM

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