Fibromyalgia (FM) & the serotonin pathway

Fibromyalgia syndrome is a musculoskeletal pain and fatigue disorder
manifested by diffuse myalgia, localized areas of tenderness,
fatigue, lowered pain thresholds, and nonrestorative sleep.
Evidence from multiple sources support the concept of
decreased flux through the serotonin pathway in fibromyalgia
patients. Serotonin substrate supplementation, via
L-tryptophan or 5-hydroxytryptophan (5-HTP), has been shown to
improve symptoms of depression, anxiety, insomnia and somatic
pains in a variety of patient cohorts. Identification of low
serum tryptophan and serotonin levels may be a simple way to
identify persons who will respond well to this approach.

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