Fibromyalgia and Depression
– Source: Pain Research and Treatment, Nov 19, 2011
By Richard H Gracely, Marta Ceko, M Catherine Bushnell
[Note: The full text of this article is available free at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236322/?tool=pubmed]
Fibromyalgia and depression might represent two manifestations of affective spectrum disorder. They share similar pathophysiology and are largely targeted by the same drugs with dual action on serotoninergic and noradrenergic systems.
Here, we review evidence for genetic and environmental factors that predispose, precipitate, and perpetuate fibromyalgia and depression and include laboratory findings on the role of depression in fibromyalgia.
Further, we comment on several aspects of fibromyalgia which support the development of reactive depression, substantially more so than in other chronic pain syndromes.
However, while sharing many features with depression, fibromyalgia is associated with somatic comorbidities and absolutely defined by fluctuating spontaneous widespread pain.
Fibromyalgia may, therefore, be more appropriately grouped together with other functional pain disorders, while psychologically distressed subgroups [may be] grouped additionally or solely with affective spectrum disorders.
Source: Pain Research and Treatment, Nov 19, 2011. PMID:22191023, by Gracely RH, Ceko M, Bushnell MC. Center for Neurosensory Disorders, University of North Carolina, Chapel Hill, NC, USA; Alan Edwards Centre for Research on Pain, Integrated Program in Neuroscience, and Departments of Anesthesia and Neurology & Neurosurgery, McGill University, Montreal, QC;, Canada.[ Email: email@example.com]