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Fibromyalgia Itching: What Causes It and How to Make It Stop

Can fibromyalgia cause itching all over? Yes, it absolutely can. It’s not one of the fibromyalgia symptoms [1] we hear about very often, but it’s one that can drive you crazy if you have it.

Fibromyalgia itching, also called pruritus, is actually more common than most people realize. According to a 2016 Turkish study [2], “We found pruritus as a symptom in 69.5% of the FMS patients in our study.”

It should be noted that a 2014 Mayo Clinic study [3] only reported finding itching as symptom in 3.3% of fibromyalgia patients. However, that study did not talk to or even survey FM patients. Instead, it simply reviewed the charts of 845 patients with a fibromyalgia diagnosis [4] to determine common dermatologic manifestations. Since itching is not one of the primary fibromyalgia symptoms most people see their doctor about or even mention during a regular visit, the results are not surprising. I suspect if the patients had been asked specifically about itching, the final tally would have resulted in a much higher percentage.

Despite the fact that we don’t hear a lot about fibromyalgia itching, you might be surprised to learn that itching is actually one in a very long list of possible “general” fibromyalgia symptoms included in the 2010 Fibromyalgia Diagnostic Criteria [5] proposed by the American College of Rheumatology.

What Causes Fibromyalgia Itching?

A single cause for the itching many fibromyalgia patients experience has yet to be identified. There are, however, a few possibilities:

Hypersensitivity (central sensitization) – It is well known that fibromyalgia causes a sensitization of the central nervous system, resulting in a hypersensitivity to pain. In addition to being hypersensitive to pain, most fibromyalgia patients find themselves to be hypersensitive to other stimuli as well, such as smells, noise, light, chemicals, and even foods. (Hence the large number of people with fibromyalgia who suffer with a variety of allergies.) It’s possible that hyperactive nerve fibers could be causing an itching sensation in some fibromyalgia patients.

Serotonin – A 2014 study, published in the journal Neuron [6], found that abnormal levels of the neurotransmitter serotonin caused mice to itch. They also discovered that the release of serotonin in response to pain activates receptors that cause itchiness. Therefore, when the body releases serotonin in response to fibromyalgia pain, it could be activating receptors that result in itching.

Medication side effects – Unfortunately, many of the medications most frequently used to treat fibromyalgia have itching as a common side effect. Some of those medications include:

How to Make the Itching Stop

Regardless what’s causing the itching, all you really want is to make it stop. If you think your itching may be caused by one of the possibilities discussed above, here are some suggestions to talk to your doctor about:

OTC Medications and Natural Remedies for Itching

Additionally there are a number of OTC medications and natural remedies that can help reduce and even eliminate itching.

Preventing Fibromyalgia Itching

In addition to treating the itch once it begins, there are some preventive measures you can take to help minimize the changes of it starting at all.

When Itching Becomes a Serious Problem

If you are experiencing extreme itching to the point that it interferes with your sleep or causes you to scratch so hard that your skin bleeds and/or becomes infected, it’s important to discuss it with your doctor.

Karen Lee Richards is ProHealth’s Editor-in-Chief. A fibromyalgia patient herself, she co-founded the nonprofit organization now known as the National Fibromyalgia Association (NFA) in 1997 and served as its vice-president for eight years. She was also the executive editor of Fibromyalgia AWARE magazine. After leaving the NFA, Karen served as the Guide to Fibromyalgia and Chronic Fatigue Syndrome for the New York Times website About.com, then worked for eight years as the Chronic Pain Health Guide for The HealthCentral Network before coming to ProHealth. To learn more about Karen, see “Meet Karen Lee Richards [9].”


https://www.sciencedirect.com/science/article/pii/S1027811716000070 [2]

Laniosz V, Wetter DA, Godar DA. Dermatologic manifestations of fibromyalgia. Clin Rheumatol. 2014 Jul;33(7):1009-13. doi: 10.1007/s10067-014-2488-3. [3]

Wolfe F, Clauw DJ, Fitzcharles MA, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken). 2010 May;62(5):600-10. doi: 10.1002/acr.20140 [10].

Zhao ZQ, Liu XY, Jeffry J, et al. Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling. Neuron. 2014 Nov 19;84(4):821-34. doi: 10.1016/j.neuron.2014.10.003 [6].