Fibromyalgia Patients Have High Levels of TNF-a but No Circadian Variation

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Lack of Circadian Pattern of Serum TNF-α and IL-6 in Patients with Fibromyalgia Syndrome.

By Ghizal Fatima, et al.

Abstract:

The present study was designed to test the hypothesis of a circadian [recurring naturally on a twenty-four-hour cycle] variation in circulating levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in women with fibromyalgia syndrome (FMS).

Serum levels of IL-6 and TNF-α were measured at 4  h intervals of the day in 50 women with FMS satisfying American College of Rheumatology criteria for FMS (age 36.68  ±  9.89) as well as 50 healthy control women (age 32.82  ±  10.53).

  • Serum TNF-α levels were substantially increased in patients with FMS but showed no circadian variation.

  • In contrast, no difference in the levels of IL-6 was found.

  • Moreover, there was also no circadian variation in both the groups of patients and controls.

We conclude that no circadian pattern exists in the circulating levels of serum IL-6 and TNF-α in patients with FMS, although TNF-α levels are found raised in patients with FMS.

Source: Indian Journal of Clinical Biochemistry, October 2012. By Ghizal Fatima, Abbas Ali Mahdi, Siddharth Kumar Das, Baby Anjum, Nar Singh Verma, Puneet Kumar, and Ragini Shrivastava. Department of Rheumatology & Biochemistry, Chhatrapati Shahu.

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