Fibromyalgia: Terra Incognita

Journal: Journal of Musculoskeletal Pain. Vol. 14(4) 2006:5-10 [Abstract/article is in online prepublication first draft version only as of October 11, 2006. Copies of final article will be available for a fee from The Haworth Document Delivery Service: 1-800-HAWORTH, E-mail, and Website] Author and Affiliation: J. Eisinger, Unit Infomyalgie, Centre Hospitalier, B.P. Toulon, France [Address Correspondence to or] DOI: 10.1300/J094v14n04_02

Objective: Biochemical abnormalities have been observed in Fibromyalgia Syndrome [FMS] patients’ blood, cerebrospinal fluid, urine, and/or muscles. Such irregularities include decreased serotonin, increased substance P and nerve growth factor, cytokines abnormalities, hypothalamic-pituitary-adrenal axis dysfunction, and decreased growth hormone. Abnormalities of energy metabolism and antioxidant status have also been observed. Correlations with clinical symptoms have been demonstrated, and all these different parameters can be linked to FMS pathophysiology as summarized by a complex figure.

Conclusion: The interactivity of biochemicals abnormalities observed in FMS has been summarized in a complex matrix. It is hoped that this diagrammatic insight will lead to novel or more appropriate treatments.

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