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Folate & other B vitamins support ‘drastic improvements’ in those with ‘migraine gene’

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“The success of our trial… has shown that safe, inexpensive vitamin supplements can treat migraine patients.”

The most recent in a series of migraine trials conducted by the Genomics Research Centre of Australia’s Griffith University “provided vitamin B supplements and folic acid to more than 50 long-term migraine sufferers for six months,” says the Center’s director, Professor Lyn Griffiths. “Results showed a drastic improvement in headache frequency, pain severity and associated disability for those treated.”

Previous studies by the Center identified a gene, known as MTHFR, which makes people susceptible to migraine attacks when there is a mutation or dysfunction in the gene.

The dysfunction causes people to have higher levels of the amino acid homocysteine, which is known to cause an increased risk of stroke and other coronary diseases.

“The recent trial was founded on the theory that vitamin B supplements and folic acid will reduce the homocysteine and in turn, improve migraine symptoms,” Griffith explains.

“The success of our trial – supported by the Brain Foundation, Janssens and Blackmores – has shown that safe, inexpensive vitamin supplements can treat migraine patients. We are now going to undertake a more extensive trial and further studies to find out the best dosage of vitamin supplements for individuals as this may vary depending on a patient’s genetic profile.”

A migraine attack causes severe headache with associated nausea and vomiting. It is a devastating disorder that affects approximately 12 per cent of the Australian population.

Professor Griffiths said there was a real need to develop effective treatments to help those afflicted with migraine. “Current treatments for migraine are not always effective and can be expensive and cause adverse effects,” she said.

Professor Griffiths’ work is at the forefront of personalized medicine, tailoring medical care to an individual’s genetic profile, which is a far safer and more efficient method of prescribing treatment.

Professor Griffiths’ team is a world leader in identifying genes associated with migraine disorders and was the first to show that variations in hormonal-pathway and blood-flow related genes are linked with the disorder.

The Genomics Research Centre has established a significant bank of population genomic resources, including the world’s largest collection of DNA samples from migraine patients, multi-generational pedigrees, and samples from the unique isolated founder-population from South Pacific’s Norfolk Island.


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Source: Griffith University Genomics Research Center (Australia) news release, Feb 4, 2009, by Sabrina Rashid [E-mail:
s.rashid@griffith.edu.au]

Note: This information has not been evaluated by the FDA. It is generic and is not meant to prevent, diagnose, treat or cure any illness, condition, or disease. It is very important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.

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One thought on “Folate & other B vitamins support ‘drastic improvements’ in those with ‘migraine gene’”

  1. TrudyBird says:

    Bravo! As a migraine sufferer for the last 27 years, it was just a year ago that I made some huge changes in what I chose to put in my body.

    At 56 years of life I decided it was time to go off my HRT and start a program of food based vitamin B supplements. I also started Fosomax for minor bone loss as well.

    I had done my own research and my doctor concurred it was worth trying to see if it helped my weekly migraines that often made me miss work and greatly affected my quality of life.

    This April, I can joyously report that I have not had a migraine in one year!!

    Research! Be your own health advocate and always communicate with your doctor. Work together and you will find answers and relief.

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