Some Patients Recommend Solutions for IBS
I also endured IBS-D for at least 40 years,. It was embarrassing, and nothing really helped except Cholestryamine and Immodium. Last year, however, I saw a specialist about an unrelated issue, and after reading my history said, "why are you putting up with this?" I told him I wasn't there for IBS – I was used to it, but he continued. He checked my blood, found I was severely malnourished ( though I eat a healthy, balanced diet) because of my IBS- D. He said, "No gluten, no dairy"……within days things began to change. He gave me supplements to heal my gut (for about 3 months). Within 6 months, I can confidently say I am free of IBS-D, I did not believe this was possible. It is, for me, a small price to pay for not worrying about bathrooms after every meal. – rskra
IBS is often cured – gone forever with 4.5mg of low dose naltrexone. Might not work for everyone but there have been enough success stories that it is worth trying. I use the word cure – not afraid to do so when something is gone for years even when not taking the LDN. I strongly urge everyone to research ldn and IBS… – panet
Quality of Life After Antidepressants
This is scary as heck! I certainly hope that more studies are done very soon about this. I am just getting ready to try Cymbalta. I had a horrible reaction to Lyrica–though it helped pain tremendously. This information in this study, even though about a very small study, makes me extremely reluctant to try Cymbalta or Savella. – bfmanning
Brainstem Dysfunction in FM Patients
I studied reflex and other prepulse inhibition under the influence of cannabinoids. This same phenomenon occurs under the influence of many neurological drugs. It also occurs in some forms of schizophrenia. It implies to me that the immune system cyokines, probably Il-6 and TNF-alpha as well as chronically elevated IFN-gamma are behind this lack of excitation inhibition maybe via impaired neuron-mitochondrial function. – IanH
I Disagree with FM and Celiac Disease Study Results
I completely disagree with what is said here.. I was diagnosed with fibro myalgia 2 years ago and I was in so much pain it was unbearable, and I was only 19 at the time and I used to be athletic, I had tendinitis in almost every place possible, back pain that limited me from so much, nausea every single day and NOTHING worked the doctors just kept saying it was fibro myalgia and gave me more meds.. finally my boyfriend suggested I go gluten free and i did, eventually 100% and guess what a year later ALL my pains and nausea are gone! And I'm off all the meds Dr's had me on.. moral of the story people with fibro myalgia should be tested for celiac or go on a GF diet bwcause if I didn't I wouldnot be happy and living life again. – dancer4109
Epigenetics Study Points to Treatment Possibilities
What a great study. It shows just how deep this illness goes. I would like to see the same study done on people with ME. Some of the genes involved will be slightly different but some will be the same. I do suspect the elevated levels of micronuclei will be similar. Also the aberrant methylation should show up similarly.
Treatment! Well it does point us in a direction of nutritional epigenetics. Current treatments are hopeless.
In the nutritional field, epigenetics is very important, because nutrients can affect the expression of genes at the transcriptional level. Folate, B-12, methionine, choline, and betaine can affect DNA methylation and histone methylation through altering 1-carbon metabolism.
Two metabolites of 1-carbon metabolism can affect methylation of DNA and histones: S-adenosylmethionine (AdoMet)5, which is a methyl donor for methylation reactions, and S-adenosylhomocysteine (AdoHcy), which is a product inhibitor of methyltransferases.
Other water-soluble B vitamins like b7, b3, and b5 also play important roles in histone modifications. B7 (biotin) is a substrate of histone biotinylation. B3 (niacin) is involved in histone ADP-ribosylation as a substrate of poly(ADP-ribose) polymerase as well as histone acetylation as a substrate of Sirtuin1, which functions as histone deacetylase (HDAC).
NAD-dependent protein deacetylase links transcription regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. It modulates chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, which leads to transcriptional repression. It deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively
Pantothenic acid is a part of CoA to form acetyl-CoA, which is the source of acetyl group in histone acetylation.
Some food components directly affect enzymes involved in epigenetics. Eg, genistein and tea catechin affects DNA methyltransferases. Resveratrol inhibits HDAC and curcumin inhibits histone acetyltransferases (HAT).
There is plenty to do now with your treatment. No cure sure but you can influence your FM by increasing the substrates that control methylation. – IanH