Full Text of Report Detecting XMRV in 22% of Prostate Cancer Patients – Available Now

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Note: The abstract of this report by cancer researchers Bryan Danielson, Gustavo Ayala, and Jason Kimata at Baylor College of Medicine, published online Nov 15, 2010 by the Journal of Infectious Diseases is provided below. It concludes "the presence of XMRV in normal tissue suggests that infection may precede cancer onset."

To read the free full text of the article go to: http://jid.oxfordjournals.org/content/202/10/1470.long

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ABSTRACT

Title: Detection of Xenotropic Murine Leukemia Virus-Related Virus in Normal and Tumor Tissue of Patients from the Southern United States with Prostate Cancer is Dependent on Specific Polymerase Chain Reaction Conditions

Background: There are questions regarding the prevalence of xenotropic murine leukemia virus-related virus (XMRV) in patients with prostate cancer and its association with the RNASEL R462Q polymorphism. [This gene variant has been associated with increased susceptibility to prostate cancer.]

We therefore investigated whether XMRV infection could be found in patients with prostate cancer from the southern United States, and we sought to verify the association with the R462Q.

Methods: Prostate tissue specimens of 144 patients with prostate cancer from the southern United States were genotyped for R462Q by real time polymerase chain reaction allelic discrimination and were screened for XMRV proviral DNA by nested polymerase chain reaction specific for the env gene.

Results:

• The R462Q polymorphism was found at an allelic frequency of 0.33.

•  XMRV was detected in 32 (22%) of the 144 patients.

•  Patients were significantly more likely to test positive for XMRV in both tumor and normal tissue rather than either alone (K = 0.64).

• A positive result for XMRV was not significantly correlated with the R462Q polymorphism (P = .82) or clinical pathological parameters of prostate cancer, including Gleason score (P = .29).

Conclusions: XMRV is detectable in normal and tumor prostate tissue from patients with prostate cancer, independent of R462Q. The presence of XMRV in normal tissue suggests that infection may precede cancer onset.

Source: Journal of Infectious Diseases, Nov 15, 2010. PMID: 20936978, by Bryan P. Danielson, Gustavo E. Ayala, and Jason T. Kimata. Departments of Molecular Virology and Microbiology and Pathology, and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA. [Email: jkimata@bcm.tmc.edu]

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One thought on “Full Text of Report Detecting XMRV in 22% of Prostate Cancer Patients – Available Now”

  1. aidanwalsh says:

    a very low percentage to ever rule xmrv/mlv as any cause when the estimates are at 100% in c.pneumonaie, mycoplasmas and ciguetera epitope toxins…i will say it again xmrv will be thrown in the bin… http://www.watercure.com http://www.watercure2.org is any chronic illnesses hope even in cfs, cancers and including hiv infection…azt causes aids and cocktails will not be ever successful in cfs…the only thing they will do is cause aids in cfs…mark my words here that cfs can be caused by ‘chronic unintentional dehydration’ an could be a non-infection illness…every major drug in cfs that helped people recover was done with a daily increase of water intakes…look at all the studies with any success and the paper mentions water as part of the protocol and that is a fact….

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