Functional anatomy of hypnotic analgesia: a PET study of patients with fibromyalgia (FM)

Hypnosis is a powerful tool in pain therapy. Attempting to
elucidate cerebral mechanisms behind hypnotic analgesia, we
measured regional cerebral blood flow with positron emission
tomography in patients with fibromyalgia, during
hypnotically-induced analgesia and resting wakefulness. The
patients experienced less pain during hypnosis than at rest.
The cerebral blood-flow was bilaterally increased in the
orbitofrontal and subcallosial cingulate cortices, the right
thalamus, and the left inferior parietal cortex, and was
decreased bilaterally in the cingulate cortex. The observed
blood-flow pattern supports notions of a multifactorial nature
of hypnotic analgesia, with an interplay between cortical and
subcortical brain dynamics. Copyright 1999 European Federation
of Chapters of the International Association for the Study of
Pain.

Wik G, Fischer H, Bragee B, Finer B, Fredrikson M

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