Gingko Beneficial to Arthritis Sufferers

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(Editor’s note: the following is a summary of an abstract originally published in Planta Med)

Ginkgo biloba, long known for its memory enhancing properties, may provide relief to painful inflammation common to arthritis sufferers.

Researchers studied the anti-inflammatory and painkilling properties of Ginkgo, used extensively in Chinese medicine for over five thousand years. The scientists extracted a compound called gingketin from Ginkgo leaves and injected it into the lining of the rats’ abdomens. The gingketin reduced arthritic inflammation more than the anti-inflammatory agent prednisolone, a steroid-type drug.

Planta Med 1999 Jun;65(5):465-7

Abstract

Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves.

Kim HK, Son KH, Chang HW, Kang SS, Kim HP

Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2. In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) strongly reduced arthritic inflammation in an animal model of rat adjuvant-induced arthritis (86% inhibition at 16 days at a dose of 20 mg/kg/day) via intraperitoneal injection, while prednisolone (5 mg/kg/day) showed 79% reduction. Histological examination of the knee joints confirmed our findings. When analgesic activity was measured, ginkgetin showed a dose-dependent inhibition in an animal model of acetic acid-induced writhing. ED50 values for ginkgetin and indomethacin were 8.9 and 3.8 mg/kg, respectively. All these results indicate that ginkgetin may be a potential antiarthritic agent having analgesic activity.

PMID: 10418340, UI: 99346894

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