OBJECTIVE: Primary fibromyalgia (FM) is a painful condition,
generally treated by analgesic drugs and antidepressants,
which has been associated with hyperpyruvicemia and reduced
high energy phosphate in muscle. Biological investigations
were performed in patients with FM to determine whether this
syndrome was related to carbohydrate metabolism impairment.
METHOD: Glycolysis was studied in 25 patients with FM, 10
patients with hypothyroidism (HO), 15 patients with
osteoarticular chronic pain (OACP), and 36 healthy controls.
Laboratory studies were performed on whole blood (pyruvate),
erythrocytes (pyruvate kinase, 2-3 diphosphoglycerate,
glyceraldehyde phosphodeshydrogenase, adenosine triphosphate),
plasma and serum (lactate at rest and after forearm ischemic
exercise, lactico deshydrogenase iso-enzymes).
Comparisons between study groups and controls demonstrated
increased pyruvate and decreased lactate production in FM and
HO; adenosine triphosphate and muscular isoenzymes of
lacticodeshydrogenase were decreased in FM only; glycolysis
was not significantly impaired in OACP.
findings provide support that FM is associated with
biochemical abnormalities which require appropriate metabolic
Eisinger J, Plantamura A, Ayavou T