Glycolysis abnormalities in fibromyalgia (FM)

OBJECTIVE: Primary fibromyalgia (FM) is a painful condition,

generally treated by analgesic drugs and antidepressants,

which has been associated with hyperpyruvicemia and reduced

high energy phosphate in muscle. Biological investigations

were performed in patients with FM to determine whether this

syndrome was related to carbohydrate metabolism impairment.

METHOD: Glycolysis was studied in 25 patients with FM, 10

patients with hypothyroidism (HO), 15 patients with

osteoarticular chronic pain (OACP), and 36 healthy controls.

Laboratory studies were performed on whole blood (pyruvate),

erythrocytes (pyruvate kinase, 2-3 diphosphoglycerate,

glyceraldehyde phosphodeshydrogenase, adenosine triphosphate),

plasma and serum (lactate at rest and after forearm ischemic

exercise, lactico deshydrogenase iso-enzymes).


Comparisons between study groups and controls demonstrated

increased pyruvate and decreased lactate production in FM and

HO; adenosine triphosphate and muscular isoenzymes of

lacticodeshydrogenase were decreased in FM only; glycolysis

was not significantly impaired in OACP.


findings provide support that FM is associated with

biochemical abnormalities which require appropriate metabolic


Eisinger J, Plantamura A, Ayavou T

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