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Greater magnesium intake from food and supplements associated with decreased fracture risk

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Reprinted with the kind permission of Life Extension.

June 30 2017. A study reported on June 20, 2017 in the British Journal of Nutrition provides a link between increased intake of magnesium and a lower risk of developing a fracture over an 8-year follow-up period.

The investigation included 1,577 men and 2,071 women enrolled in the Osteoarthritis Initiative, an ongoing, multicenter, longitudinal U.S. study. Questionnaires completed upon enrollment provided data concerning magnesium intake from supplements and diet. Only 27% of the subjects had an intake of magnesium that met the U.S. recommended daily allowance (RDA) of 420 milligrams (mg) for men and 320 mg for women.

Over an 8-year follow-up period, 198 men and 368 women developed a fracture. Men whose intake of magnesium was among the top 20% of subjects had a 53% lower adjusted risk of fracture in comparison with those whose intake was among the lowest 20%, and for women, the risk experienced by those among the top intake category was 62% lower. Women whose intake of magnesium met the U.S. RDA had a 27% lower risk of fracture than those who failed to consume this amount.

As potential mechanisms, Nicola Veronese and colleagues observe that magnesium positively influences osteoblast and osteoclast function, and plays a role in the modulation of calcium homeostasis via its contribution to calcitriol and parathyroid regulation. Magnesium also helps combat inflammation which is associated with fracture and osteoporosis, and contributes to muscle strength, thereby reducing the risk of falls.

“Higher dietary magnesium intake has a protective effect on bone osteoporotic fractures, particularly in women, suggesting an important role of this mineral in osteoporosis and fractures,” the authors conclude. “Further randomized controlled trials are needed to understand the possible role of magnesium in delaying fractures.”

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