We report two cases of
Lyme disease, revealed by hepatic damage in a 71- and a 59-year old man. In the first case, the
disease was revealed by febrile jaundice whereas, in the second case, results of liver tests showed cytolytic and cholestatic abnormalities with fever.
Lyme disease is a zoonosis due to infection by Borrelia burdorferi transmitted by ticks. The multiple phases of the
disease explain the polymorphism of the clinical manifestations. Usually, extrahepatic symptoms are first observed, including neurological tropisms of Borrelia burdorferi. On the contrary, hepatic impairment due to
Lyme disease is rare, often asymptomatic and with biological manifestations only.