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Higher vitamin D levels may be protective against acute rhinosinusitis

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Reprinted with the kind permission of Life Extension.

October 21 2015. The October 2015 issue of the journal Medicine reported the outcome of a study of participants in the National Health and Nutrition Examination Survey (NHANES) 2001-2006 which found a lower incidence of acute rhinosinusitis among men and women with higher levels of serum vitamin D. Acute rhinosinusitis affects an estimated 30 million or more Americans per year and, while caused mainly by viral infections, is the fifth leading cause of antibiotic prescriptions.

The analysis included 3,921 subjects aged 17 and older whose blood samples were analyzed for serum 25-hydroxyvitamin D. Approximately 16% of the subjects reported having a cold, sinus problem or earache within the preceding 24 hours of interviews that were conducted upon enrollment.
Vitamin D levels of 0-9.9 nanograms per milliliter (ng/mL) were found in 7.1% of the participants, 33.7% had levels of 10-19.9 ng/mL and 40% had levels ranging from 20-29.9 ng/mL. Compared to subjects whose vitamin D levels were 20 ng/mL or more, those with lower levels had a 33% greater risk of acute rhinosinusitis within 24 hours of their interview. Each 10 ng/mL increase in vitamin D was determined to be associated with a 12% reduction in risk.
"Although previous studies have shown that vitamin D status is associated with the risk of various respiratory diseases, our work provides important supporting evidence to suggest that appropriate vitamin D supplementation may offer a novel approach to lowering the risk of acute rhinosinusitis and by extension the risk of chronic rhinosinusitis in the general population," Ayesha N. Khalid, MD, MBA, and colleagues write.  "High-quality, randomized controlled trials are warranted to determine whether vitamin D supplementation in individuals with low vitamin D status may affect the incidence and severity of acute rhinosinusitis in the general population."

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