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Hormonal alterations in adolescent chronic fatigue syndrome – Source: Acta Paediatrica, Mar 1, 2010

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[Note: plasma osmolality is the concentration of substances such as sodium, potassium, glucose, etc. in the blood, which is affected by changes in water content. This concentration increases with dehydration, and decreases with overhydration. In normal people, increased concentration stimulates secretion of antidiuretic hormone which in turn increases water reabsorption and causes more concentrated urine & less concentrated blood plasma. Renin levels in the blood play a major role in blood pressure regulation, thirst, and urine output.]

Aim: The chronic fatigue syndrome is associated with alterations in the hypothalamus-pituitary-adrenal axis and cardiovascular autonomic nervous activity, suggesting a central dysregulation.

This study explored differences among adolescent chronic fatigue syndrome patients and healthy controls regarding antidiuretic hormone, the renin-angiotensin-aldosterone-system, sex hormones and cardiac peptides.

Methods: We included a consecutive sample of 67 adolescents aged 12-18 years with chronic fatigue syndrome diagnosed according to a thorough and standardized set of investigations, and a volunteer sample of 55 healthy control subjects of equal gender and age distribution.

Hormones were assayed with standard laboratory methods.

Results: Among patients:
• Plasma antidiuretic hormone was significantly decreased
• And serum osmolality and plasma renin activity were significantly increased (p </= 0.001).
• Serum concentration of aldosterone, cortisol, NT-proBNP and sex hormones were not significantly different in the two groups.

Conclusion: Chronic fatigue syndrome in adolescents is associated with alterations in hormonal systems controlling osmolality and blood volume, possibly supporting a theory of central dysregulation.

Source: Acta Paediatrica, Mar 1, 2010. PMID: 20199497, by  Wyller VB, Evang JA, Godang K, Solhjell KK, Bollerslev J. Division of Paediatrics and Department of Endocrinology,  Oslo University Hospital, Oslo, Norway. [Email: brwylle@online.no]

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