Hormone replacement therapy associated with lower risk of dying over eight year follow-up period

Reprinted with the kind permission of Life Extension.

March 17 2017. The American College of Cardiology’s 66th Annual Scientific Session was the site of a presentation concerning a recent study that uncovered a lower risk of mortality over an eight year average follow-up period among women using hormone replacement therapy.

Yoav Arnson, MD, and colleagues analyzed data from over 4,200 women who received coronary calcium computed tomography (CT) scans at Cedars-Sinai Medical Center between 1998 and 2012. Forty-one percent of the women were using hormone replacement therapy at the time of their scans.

Over an average follow-up period of eight years, 6% of the subjects died. Following adjustment for age, coronary calcium score and cardiovascular risk factors, women using hormone replacement therapy were found to have a 30% lower risk of death than those who did not use hormone therapy. Subjects who used hormone replacement therapy were 20% more likely to have the lowest possible coronary calcium score of zero, which indicates a low likelihood of heart attack, and were 36% less likely to have a score above 399, which is indicative of severe atherosclerosis.

“Hormone replacement therapy resulted in lower atherosclerosis and improved survival for all age groups and for all levels of coronary calcium,” stated Dr Arnson, who is a postdoctoral scientist at Cedars-Sinai Medical Center. “From this we do think it is beneficial, but we would need prospective or randomized studies to determine which groups might not benefit or even be harmed by this therapy.”

“With proper screening and proper follow-up, from a cardiovascular standpoint I believe it is beneficial to take hormone replacement therapy,” she added. “Our results confirm and enhance previous work in terms of showing lower atherosclerosis. In addition, we’ve shown very clear survival benefits of using hormone replacement therapy.”

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