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Host-pathogen interactions and the pathogenesis of murine Lyme disease.


Lyme disease results from persistent infection with the spirochete Borrelia burgdorferi. A combination of bacterial factors and host factors contributes to the development of inflammatory
disease. Studies from the past year have provided insight into both sides of this host-pathogen interplay. We now have a better appreciation of the bacterial genes and products that are involved in pathology and the components of the host response that participate in
disease development.

Curr Opin Rheumatol. 2002 Jul;14(4):399-403. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.; Review [1]