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How do lyme borrelia organisms cause disease? The quest for virulence determinants().

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Abstract

Lyme disease Borrelia are invasive, nontoxigenic, persistent pathogens, and little is known about their mechanisms of pathogenesis. In our laboratory, a signature-tagged mutagenesis (STM) library of over 4,000 Borrelia burgdorferi transposon mutants has been constructed and is being screened for infectivity in mice. In this manner, a global view of the virulence determinants (factors required for full infectivity) is being developed. Additionally, the mechanisms of immune evasion involving the VMP-like system (vls) are under analysis, and cryo-electron microscopy is providing a detailed view of the three-dimensional structure of B. burgdorferi. These approaches will contribute to the improved understanding of how
Lyme disease Borrelia cause
disease.

Open Neurol J. 2012;6:119-23. doi: 10.2174/1874205X01206010119. Epub 2012 Oct 5.

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