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Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans.
Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark.
PATIENT AND RESULTS:
Two weeks after his second Pandemrix-vaccination, a 10 year old HLA-DQB1*0602-positive boy developed NC. The CSF hypocretin-1 level was 10 pg/ml. However, CSF saved from a pre-narcolepsy episode of
Lyme disease revealed a normal hypocretin-1 level (318 pg/ml).
We confirm that hypocretin deficiency develops in parallel to the onset of human narcolepsy with cataplexy.