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Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis.

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Abstract

Treatment-resistant
Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of
Lyme disease, and the major histocompatibility complex class II allele DRB1*0401. The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function-associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant
Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune
disease.

Science. 1998 Jul 31;281(5377):703-6. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.

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