[Note: IgM antibodies – one of the five major types of antibodies – are the first type made in response to an infection.]
The study investigated the presence of Borrelia-specific antibodies captured in immune complexes (ICs) in patients with early Lyme disease manifested by erythema migrans.
Out of 18 patients, 15 (83.3%) tested positive for polyethylene glycol-precipitated ICs containing IgM antibodies, while only 4 (22.2%) were IgG positive.
These results are in accordance with our findings obtained by standard ELISA and recombinant blot, which indicated that ICs might be used for serological diagnosis of the early disease.
Source: Canadian Journal of Microbiology. Dec 2007;53(12):1375-7. PMID: 18059570, by Lencakova D, Stefancíkova A, Ivanova R, Petko B. Department of Natural Foci Diseases, Parasitological Institute of Slovak Academy of Sciences, Kosice, Slovakia.