Immunoglobulin subclass levels in Chronic Fatigue Syndrome (CFS)

The levels of immunoglobulin subclasses were determined for 46

patients meeting the original Centers for Disease Control case

definition of chronic fatigue syndrome and were compared to

values obtained for 50 age- and gender-matched healthy

volunteer blood donor controls. The levels of immunoglobulin

subclasses in these groups were further compared to a third

group of additional chronic fatigue syndrome cases from whom

samples had been obtained and frozen prospectively over a

period of 7 years. These data do not demonstrate significant

immunoglobulin subclass deficiencies in patients with chronic

fatigue syndrome.

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