This study was conducted to evaluate the immunological
response to an exhaustive treadmill exercise test in 20 female
chronic fatigue syndrome patients compared to 14 matched
sedentary controls. Venipuncture was performed at baseline and
4 min, 1 hr, and 24 hr postexercise. White blood cells were
labeled for monoclonal antibody combinations and were
quantified by FACsan. Cytokines were assayed utilizing
quantitative RT/PCR. No group difference was seen in VO2peak
(28.6 +/- 1.6 vs 30.9 +/- 1.2 ml.kg-1.min-1; P > 0.05).
However, 24 hr after exercise the patients’ fatigue levels
were significantly increased (P < 0.05). The counts of WBC,
CD3+ CD8+ cells, CD3+ CD4+ cells, T cells, B cells, natural
killer cells, and IFN-gamma changed across time (P’s < 0.01).
No group differences were seen for any of the immune variables
at baseline or after exercise (P’s > 0.05). The immune
response of chronic fatigue syndrome patients to exhaustive
exercise is not significantly different from that of healthy
nonphysically active controls.
LaManca JJ, Sisto SA, Zhou XD, Ottenweller JE, Cook S, Peckerman A,
Zhang Q, Denny TN, Gause WC, Natelson BH