Immunological response in Chronic Fatigue Syndrome (CFS) following a graded exercise test to exhaustion

This study was conducted to evaluate the immunological

response to an exhaustive treadmill exercise test in 20 female

chronic fatigue syndrome patients compared to 14 matched

sedentary controls. Venipuncture was performed at baseline and

4 min, 1 hr, and 24 hr postexercise. White blood cells were

labeled for monoclonal antibody combinations and were

quantified by FACsan. Cytokines were assayed utilizing

quantitative RT/PCR. No group difference was seen in VO2peak

(28.6 +/- 1.6 vs 30.9 +/- 1.2 ml.kg-1.min-1; P > 0.05).

However, 24 hr after exercise the patients’ fatigue levels

were significantly increased (P < 0.05). The counts of WBC,

CD3+ CD8+ cells, CD3+ CD4+ cells, T cells, B cells, natural

killer cells, and IFN-gamma changed across time (P’s < 0.01).

No group differences were seen for any of the immune variables

at baseline or after exercise (P’s > 0.05). The immune

response of chronic fatigue syndrome patients to exhaustive

exercise is not significantly different from that of healthy

nonphysically active controls.

LaManca JJ, Sisto SA, Zhou XD, Ottenweller JE, Cook S, Peckerman A,

Zhang Q, Denny TN, Gause WC, Natelson BH

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