Impaired oxygen delivery to muscle in Chronic Fatigue Syndrome (CFS)

1 Star2 Stars3 Stars4 Stars5 Stars (31 votes, average: 2.70 out of 5)
Loading...

The purpose of this study was to determine if chronic fatigue

syndrome (CFS) is associated with reduced oxygen delivery to

muscles. Patients with CFS according to CDC (Center for

Disease Control) criteria (n=20) were compared with normal

sedentary subjects (n=12). Muscle oxygen delivery was measured

as the rate of post-exercise and post-ischaemia oxygen-haem

resaturation. Oxygen-haem resaturation was measured in the

medial gastrocnemius muscle using continuous-wavelength

near-IR spectroscopy. Phosphocreatine resynthesis was measured

simultaneously using (31)P magnetic resonance spectroscopy.

The time constant of oxygen delivery was significantly reduced

in CFS patients after exercise (46.5+/-16 s; mean+/-S.D.)

compared with that in controls (29.4+/-6.9 s). The time

constant of oxygen delivery was also reduced (20.0+/-12 s)

compared with controls (12.0+/-2.8 s) after cuff ischaemia.

Oxidative metabolism was also reduced by 20% in CFS patients,

and a significant correlation was found between oxidative

metabolism and recovery of oxygen delivery. In conclusion,

oxygen delivery was reduced in CFS patients compared with that

in sedentary controls. This result is consistent with previous

studies showing abnormal autonomic control of blood flow.

Reduced oxidative delivery in CFS patients could be

specifically related to CFS, or could be a non-specific effect

of reduced activity levels in these patients. While these

results suggest that reduced oxygen delivery could result in

reduced oxidative metabolism and muscle fatigue, further

studies will be needed to address this issue.

McCully KK, Natelson BH

1 Star2 Stars3 Stars4 Stars5 Stars (31 votes, average: 2.70 out of 5)
Loading...



Leave a Reply