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Increased capsaicin-induced secondary hyperalgesia as a marker of abnormal sensory activity in patients with fibromyalgia (FM)

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In this study, capsaicin-induced secondary hyperalgesia was

assessed as a marker of abnormal nociceptive processing in

patients with fibromyalgia (FM). The area of mechanical

secondary hyperalgesia induced by a standard solution of

capsaicin placed on the volar forearm was measured in ten

patients with FM and the results compared to those obtained in

ten patients with rheumatoid arthritis (RA) and ten normal

subjects. The area of secondary hyperalgesia was found to be

substantially increased in both the FM and RA groups compared

with controls. In the FM group the area of hyperalgesia

correlated with the overall pain score and with the joint

tenderness score. The results suggest that in FM there is

enhanced sensitivity of nociceptive neurones at a spinal

level, thereby supporting the concept of a generalised

disturbance of pain modulation in this disorder.

1 Star2 Stars3 Stars4 Stars5 Stars (32 votes, average: 3.05 out of 5)
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