Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia (FM) & Chronic Fatigue Syndrome (CFS)

Twelve outpatients, all women, who fulfilled the criteria for both
fibromyalgia and chronic fatigue syndrome were rated on 15
items of the Comprehensive Psychopathological Rating Scale
(CPRS-15). These items were chosen to constitute a proper
neurasthenic subscale. Blood laboratory levels were generally
normal. The most obvious finding was that, in all the
patients, the homocysteine (HCY) levels were increased in the
cerebrospinal fluid (CSF). There was a significant positive
correlation between CSF-HCY levels and fatiguability, and the
levels of CSF-B12 correlated significantly with the item of
fatiguability and with CPRS-15. The correlations between
vitamin B12 and clinical variables of the CPRS-scale in this
study indicate that low CSF-B12 values are of clinical
importance. Vitamin B12 deficiency causes a deficient
remethylation of HCY and is therefore probably contributing to
the increased homocysteine levels found in our patient group.
We conclude that increased homocysteine levels in the central
nervous system characterize patients fulfilling the criteria
for both fibromyalgia and chronic fatigue syndrome.

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