Increased incidence of a resonance in the phosphodiester region of 31P nuclear magnetic resonance spectra in the skeletal muscle of fibromyalgia (FM) patients

1 Star2 Stars3 Stars4 Stars5 Stars (23 votes, average: 3.15 out of 5)
Loading...

OBJECTIVE. To determine if patients with fibromyalgia syndrome (FMS)

are more susceptible to activity-induced muscle damage than

are healthy subjects.

METHODS. Eleven FMS patients and 10

healthy subjects performed concentric and eccentric exercise

with their dominant and nondominant forearms, respectively.

31P magnetic resonance spectroscopy (to assess inorganic

phosphate [P(i)] and phosphocreatine [PCr]) and dolorimetry

(to assess pain) were performed before and 20 minutes after

exercise and at 4 subsequent 24-hour intervals.

RESULTS.

Neither group exhibited increased P(i)/PCr ratios or reduced

dolorimetry scores following the exercise protocols. FMS

patients did display a phosphodiester resonance at a higher

rate than healthy subjects (37% versus 12%), but this was not

related to the exercise.

CONCLUSION. Unchanged P(i)/PCr ratios

and dolorimetry scores following acute exercise provide

evidence against the hypothesis that FMS patients are more

susceptible to activity-induced muscle damage than are healthy

subjects, although P(i)/Pcr and pain may not adequately

document such damage. The frequent occurrence of

phosphodiester in the spectra of FMS patients may indicate a

sarcolemmal abnormality in these subjects.

MCM: The phosphodiester (PDE) peak found much more often in FM

pts is usually contributed mainly by

glycerol-3-phosphorylcholine (GPC).This compound is produced

by the action of phospholipases on phospholipids, possibly

indicating a mechanism of muscle fiber damage.

Jubrias SA, Bennett RM, Klug GA

1 Star2 Stars3 Stars4 Stars5 Stars (23 votes, average: 3.15 out of 5)
Loading...



Leave a Reply