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Inflammation Causes Fatigue, Pain and Depression (in Rheumatoid Arthritis and Other Conditions)

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 Editor’s Note: Although this study refers to those with rheumatoid arthritis (which is in some cases actually Lyme disease) the results of the study suggest that inflammation, no matter the cause, is a major cause of fatigue, pain and depression. Supporting the body’s inflammatory processes with natural agents such as curcumin, quercetin and omega EFAs may therefore be helpful for mitigating those symptoms.
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Fatigue is a frequent symptom in several inflammatory diseases, particularly in rheumatic diseases. Elements of disease activity and cognitive and behavior aspects have been reported as causes of fatigue in patients with rheumatoid arthritis. Fatigue could be associated with activity of inflammatory rheumatism.
Indeed, biologic agents targeting inflammatory cytokines are effective in fatigue. Fatigue is also associated with pain and depressive symptoms. Different pathways could be involved in fatigue and interact: the immune system with increased levels of pro-inflammatory cytokines (interleukin-1 and −6 and tumor necrosis factor alpha), dysregulation of the hypothalamic-pituitary-adrenal axis and neurological phenomena involving the central and autonomic nervous systems.
A pro-inflammatory process could be involved in pain and behavioral symptoms. Inflammation could be a common link between fatigue, pain, and depression.
Source: By Karine Louati and Francis Berenbaum. Fatigue in chronic inflammation – a link to pain pathways. Arthritis Res Ther. 2015; 17: 254.
Published online 2015 Oct 5. doi:  10.1186/s13075-015-0784-1

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