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Inflammatory cytokine production predominates in early Lyme disease in patients with erythema migrans.

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Abstract

In a study of cytokine production ex vivo by Borrelia burgdorferi-stimulated peripheral blood mononuclear cells from 27 patients with culture-positive erythema migrans, production of inflammatory cytokines predominated, particularly gamma interferon and, to a lesser degree, tumor necrosis factor alpha. In contrast, with the exception of interleukin-13, anti-inflammatory cytokine production was negligible. Thus, B. burgdorferi antigens in early
Lyme disease often induce a strong inflammatory response.

Infect Immun. 2003 Oct;71(10):6051-3. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.

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