Intravenous Micronutrient Therapy (Myers’ Cocktail) for Fibromyalgia: A Placebo-Controlled Pilot Study – Source: Journal of Alternative and Complementary Medicine, Feb 28, 2009

[Note: A Myers’ cocktail is intravenously delivered solution of nutrients that are deficient or involved in a variety of pathologies. Based on the work of the late John Meyers, MD, it typically includes magnesium, calcium, B vitamins, and vitamin C.]

Objectives: Intravenous micronutrient therapy (IVMT), and specifically the Myers’ Cocktail, is a popular approach for treating fibromyalgia syndrome (FMS) among complementary and alternative medicine practitioners, but its efficacy is uncertain. This trial assessed the feasibility, safety, and provided insights into the efficacy of this therapy.

Design: This was a randomized, double-blind, placebo-controlled pilot study.

Locations: The study locations were an academic research center, teaching hospital, and affiliated Integrative Medicine Center in Derby, CT.

Subjects: The subjects were 34 adults with American College of Rheumatology (ACR)-defined FMS.

Intervention: Subjects were randomly assigned either to treatment (weekly infusions of IVMT) or to placebo (weekly infusions of lactated Ringer’s solution) for 8 weeks.

Outcome measures:

• Primary outcome was change in the Tender Point Index, assessed 8 and 12 weeks after initiation.

• Secondary measures included a Visual Analog Scale to assess global pain, and validated measures of physical function (Fibromyalgia Impact Questionnaire), mood (Beck Depression Index), and quality of life (Health Status Questionnaire 2.0).


• Clinically significant improvements were noted (of a magnitude similar to other effective interventions).

• However, in part because of the high placebo response and the small sample size, no statistically significant differences were seen between groups, in any outcome measure, at 8 and 16 weeks.

• Statistically significant within-group differences were seen in both the intervention and placebo groups, demonstrating a treatment effect for both IVMT and placebo.

• At 8 weeks, the IVMT group experienced significantly improved tender points, pain, depression, and quality of life directly following treatment (all p </= 0.02), while the placebo group experienced significantly improved tender points only (p </= 0.05).

• The treatment effects of IVMT persisted at 4 weeks post-intervention for tender points, pain, and quality of life, while placebo effects persisted only for tender points. A single minor adverse event was noted in one subject in the intervention group.

Conclusions: This first controlled pilot study established the safety and feasibility of treating FMS with IVMT. Most subjects experienced relief as compared to baseline, but no statistically significant differences were seen between IVMT and placebo. The efficacy of IVMT for fibromyalgia, relative to placebo, is as yet uncertain.

Source: Journal of Alternative and Complementary Medicine, Feb 28, 2009. PMID PMID: 19250003, by Ali A, Njike VY, Northrup V, Sabina AB, Williams AL, Liberti LS, Perlman AI, Adelson H, Katz DL. Prevention Research Center, Yale University School of Medicine, Derby, Connecticut, USA.

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3 thoughts on “Intravenous Micronutrient Therapy (Myers’ Cocktail) for Fibromyalgia: A Placebo-Controlled Pilot Study – Source: Journal of Alternative and Complementary Medicine, Feb 28, 2009”

  1. lil_biscuit says:

    I tried Myers’ Cocktail therapy by i.v., once a week, for two hours a visit for about 8 months. Results: NOTHING! In fact, I was worse when I started. These are very expensive treatments, as well as very time consuming. When I began the treatments, I had ME/CFS. After about 4 months, I was stricken with Fibromyalgia. I cannot say these treatments induced the Fibro, but what I can say is they certainly didn’t help. I left that clinic in San Francisco (at $2800/month for treatments and supplements prescribed), much more ill than I started, devastated by the cavalier attitude displayed by the “Doctors” who were treating me, and certainly much poorer! I was so desperate to find relief, I bought into everything they proffered. I would caution anyone against this treatment protocol, and against any “Doctors” who sell the products they prescribe. Conflict of interest ring a bell? But the main message here is this: Myers’ Cocktails had no to negative effect on my condition.

  2. ophinea says:

    Those suffering from ME/CFS commonly have coexisting autonomic dysfunction such as POTS. It’s possible that either the “placebo” or the Myer’s Cocktail could have a positive short term result because of the increase in fluid volume. Check Dr. David Bell’s stuff for a much better explanation.

    PS I have to agree with the previous post – if she’s referring to the F&FC’s – *extremely* expensive, totally ineffective and borderline harmful. They shouldn’t be allowed to practice medicine.

  3. ziamarie says:

    I had one treatment of IV vits from my Dr. and experienced relief from my flu like condition of 3 months. It was not fibromyalgia, according to my Dr but I was afraid that it was…It was not expensive and my insurance paid for some of the cost. My mother was also helped by a single treatment. I just hope that people realize that while this isn’t some kind of magic bullet getting an IV might help many of us with different symptoms.

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