Is fibromyalgia (FM) a distinct clinical entity? Pain mechanisms in FM syndrome. A myologist’s view

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The cause of muscle pain and allodynia may not be the same in

all persons fulfilling the American College of Rheumatology

(ACR) criteria for fibromyalgia syndrome. In the majority of

patients the generalized pain is preceded by localized or

regional pain, usually in the musculoskeletal system. In many

patients with fibromyalgia there are findings compatible with

tissue injury pain with pain mechanisms involving both the

primary afferent neuron and the nociceptive system in the

central nervous system. Evidence for these mechanisms is

described.

Henriksson KG

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