Ketone supplementation associated with lower blood glucose

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Reprinted with the kind permission of Life Extension.

February 16 2018. A randomized, crossover study reported on February 15, 2018 in the Journal of Physiology resulted in a reduction in blood glucose and improved insulin sensitivity following the ingestion of a ketone monoester supplement by young, healthy participants. Ketones are byproducts of the breakdown of fat for the production of energy when the intake of carbohydrates is limited. Ketones have been previously shown to lower blood sugar levels when infused into the bloodstream.

Ten men and ten women between the ages of 18 and 35 years received a drink containing the ketone monoester supplement or a placebo after a 10 hour fast. This was followed one half hour later by the consumption of a drink that contained 75 grams of sugar. Blood samples were collected every 15 to 30 minutes over a 2.5-hour period and analyzed for glucose, lipids and the ketone body D-beta-hydroxybutyrate. The experiment was then repeated with treatments switched between subjects.

Among participants who received ketones, D-beta-hydroxybutyrate levels were higher and blood glucose and nonesterified fatty acid levels were significantly lower following the intake of the high sugar drink. According to authors Etienne Myette-Côté and colleagues, “The reduction in glycemic response did not appear to be driven by an increase in insulin secretion but was accompanied by improved markers of insulin sensitivity.”

“Our study was done in healthy young participants but if the same responses were seen in people with, or at risk for, type 2 diabetes then it is possible that a ketone monoester supplement could be used to lower glucose levels and improve metabolic health,” commented lead researcher Jonathan Peter Little, of the University of British Columbia’s Okanagan Campus. “We are working on these studies at the moment.”

—D Dye

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