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Laboratory evaluation in the diagnosis of Lyme disease.

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Abstract

PURPOSE:

To provide a qualitative evaluation of the predictive value of the laboratory diagnosis of
Lyme disease and to use the resultant data to formulate guidelines for clinical diagnosis.

DATA SOURCES:

A MEDLINE search of English-language articles or articles with English-language abstracts published from 1982 to 1996.

DATA EXTRACTION:

Sensitivity, specificity, and likelihood ratios were calculated, and a random-effects model was used to combine the proportions from the eligible studies. Prespecified criteria were used to determine which studies were eligible for analysis.

DATA SYNTHESIS:

Laboratory testing in general is not clinically useful if the pretest probability of
Lyme disease is less than 0.20 or greater than 0.80. When the pretest probability is 0.20 to 0.80, sequential testing with enzyme-linked immunosorbent assay and Western blot is the most accurate method for ruling in or ruling out the possibility of
Lyme disease.

CONCLUSIONS:

Laboratory testing is recommended only in patients whose pretest probability of
Lyme disease is 0.20 to 0.80. If the pretest probability is less than 0.20, testing will result in more false-positive results than true-positive results; a negative test result in this situation effectively rules out the
disease.

Ann Intern Med. 1997 Dec 15;127(12):1109-23.

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