Lack of association between fibromyalgia (FM) syndrome & abnormalities in muscle energy metabolism

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OBJECTIVE. To compare parameters of muscle energy metabolism

in patients with fibromyalgia syndrome (FMS) and sedentary

controls.

METHODS. Thirteen female FMS patients and 13 female

sedentary controls underwent a standardized clinical

assessment (including dolorimeter measurements of the upper

trapezius and tibialis anterior muscles) and a standardized

aerobic fitness test including measurement of maximum oxygen

uptake (VO2max). Phosphorus (31P) magnetic resonance

spectroscopy studies of the upper trapezius and tibialis

anterior muscles were then performed in FMS patients and

controls, at rest and during and following a muscle-fatiguing

exercise protocol.

RESULTS. FMS patients and controls had

similar levels of VO2max and of maximum voluntary contraction

(MVC) of the upper trapezius and tibialis anterior muscles.

After controlling for VO2max and MVC, measurements of

phosphocreatine (PCr), inorganic phosphate (P(i)), and

intracellular pH in these muscles were not significantly

different in FMS patients versus sedentary controls either at

rest, during exercise, or during recovery. In the patients

with FMS, no correlation was found between overall or local

pain severity and the principal muscle metabolic parameter,

PCr/P(i). Inverse correlations between dolorimeter scores at 2

muscle sites and tibialis anterior PCr/P(i) were found both in

patients and in controls.

CONCLUSION. This study demonstrates

that under the conditions studied, muscle energy metabolism in

FMS is no different than that in sedentary controls. These

findings do not support the hypothesis that detectable defects

in muscle energy metabolism occur in FMS.

Simms RW, Roy SH, Hrovat M, Anderson JJ, Skrinar G, LePoole SR,

Zerbini CA, de Luca C, Jolesz F

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