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Cardiac involvement is common in acute
Lyme disease, and case reports suggest that cardiac abnormalities might also occur years after the primary infection.
To determine the prevalence of cardiac abnormalities in persons with previously treated
Population-based, retrospective cohort study with controls.
Nantucket Island, Massachusetts.
From among 3703 adult respondents to a total-population (n = 6046) mail survey, 336 (176 case-patients and 160 controls) were randomly selected for clinical evaluation.
Current cardiac symptoms and major or minor abnormal electrocardiographic features, including heart rate; rhythm; axis; PR, QRS, and QT intervals; QRS structure; atrioventricular blocks; and ST-segment and T-wave changes.
Lyme disease (case-patients, n = 176) (mean duration from
disease onset to study evaluation, 5.2 years) and persons without evidence of previous
Lyme disease (controls, n = 160) did not differ significantly in their patterns of current cardiac symptoms and electrocardiographic findings, including heart rate (P > 0.2), PR interval (P = 0.15), QRS interval (P > 0.2), QT interval (P > 0.2), axis (P > 0.2), presence of arrhythmias (P > 0.2), first-degree heart block (P = 0.12), bundle-branch block (P > 0.2), and ST-segment abnormalities (P > 0.2). In multivariate analyses that adjusted for age, sex, and previous heart
disease, a history of previously treated
Lyme disease was not associated with either major (odds ratio, 0.78; P > 0.2) or minor (odds ratio, 1.09; P > 0.2) electrocardiographic abnormalities.
Persons with a history of previously treated
Lyme disease do not have a higher prevalence of cardiac abnormalities than persons without a history of