Low growth hormone secretion in patients with fibromyalgia–a preliminary report on 10 patients and 10 controls.

OBJECTIVE: To evaluate the secretion of growth hormone in patients with fibromyalgia (FM).

METHODS: Serum concentrations of growth hormone (24 h profiles), insulin-like growth factor I (IGF), and IGF binding protein-3 were determined in 10 women with FM and in 10 healthy controls. Quality of sleep was assessed by means of a visual analog scale.

RESULTS: Sleep was significantly more disturbed in the patients than in controls. A significantly lower secretion of growth hormone was found in the patients in comparison with healthy controls.

CONCLUSION: These results suggest that growth hormone secretion is decreased in patients with FM. Substitution therapy with low doses of growth hormone may be worth evaluating in the treatment of FM.


J Rheumatol 1998 Jan;25(1):145-148.

Department of Rheumatology, the Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden.

PMID: 9458218

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