Lyme disease is the most common of tickborne spirochetoses in France. Over fifty years, several clinical forms have been identified. Following the description of the
disease in the United States, links were recognised between the forms presenting infectious, cutaneous, neurological and rheumatic symptoms. Although its epidemiology has now been well established, this spirochetosis can still pose difficult diagnostic problems despite serological investigations. Concerning therapy, rapid treatment is highly valuable. The prescription of ceftriaxone is now highly recommended.